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尿激酶致大面积脑梗塞临床少见,现报告2例如下。例1女,55岁。因左侧轻偏瘫2天于1992年9月8日入院。查体:BP28/14kPa,神清,语言流利。心率78次/分,音纯律整。左上肢肌力Ⅲ级,左巴氏征阴性。发病6小时头部 CT“未见异常”。ECG 正常。出凝血时间正常。次日用尿激酶(南京大学制药厂生产,批号910114)10万u加25%葡萄糖200ml 静脉推注,于用药后10分钟病人逐渐意识障碍,开始昏睡,随后又用尿激酶40万 u 加0.9%生理盐水500ml 中续点,3小时后左上肢肌力0级,出现浅昏迷。20小时后再次 CT 显示右颞顶叶及右
Urokinase caused by large area of clinical cerebral infarction is rare, now report 2 cases as follows. Example 1 Female, 55 years old. Left hemiparesis due to 2 days on September 8, 1992 admission. Physical examination: BP28 / 14kPa, God clear, fluent language. Heart rate 78 beats / min, tone pure law. Left upper limb muscle strength Ⅲ grade, left lba’s sign negative. 6 hours head CT “no abnormalities.” ECG is normal. Clotting time out of normal. The next day with urokinase (Nanjing University Pharmaceutical Factory, batch number 910114) 100,000 u plus 25% glucose 200ml intravenous injection, 10 minutes after treatment, patients gradually unconsciousness, began to lethargy, followed by urokinase 400000 u plus 0.9 % Saline 500ml point, 3 hours after the left upper limb muscle strength 0, appeared shallow coma. Twenty hours later CT showed right temporal parietal lobe and right