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醛固酮是人体内最重要、作用最强的盐皮质激素,不仅可以引起水钠潴留,而且可以促进胶原合成沉积,导致心脏血管以及其他器官纤维化和结构重塑,在高血压、糖尿病、动脉粥样硬化、心脑血管疾病发生发展中起着十分重要的作用。醛固酮合酶是醛固酮合成过程中最后一步生化反应的催化酶,其编码基因为CYP11B2,其基因-344T/C多态性与心、脑血管病和血浆醛固酮水平密切相关,为近年来人们研究的热点之一。
Aldosterone is the most important and most potent mineralocorticoid in the human body. It not only causes water and sodium retention, but also promotes collagen synthesis and deposition, leading to fibrosis and structural remodeling of cardiovascular and other organs. In hypertension, diabetes, Like sclerosis, cardiovascular disease plays a very important role in the development. Aldosterone synthase is the last step of aldosterone biosynthesis catalytic enzyme catalyzing the gene encoding CYP11B2, its gene -344T / C polymorphism and heart, cerebrovascular disease and plasma aldosterone levels are closely related to people in recent years One of the hot spots.