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对138例肾脏疾病患儿的血清肿瘤坏死因子(TNF-α)活性动态变化进行了检测,并与正常健康小儿30例进行对照,结果显示①小儿肾脏疾病的急性期或肾病期TNF-α活性显著升高,与正常组对比,P<0.001,而恢复期显著下降;②小儿肾脏疾病治疗前后TNF-α活性相比,P<0.001,有非常显著性差异;③小儿肾脏疾病中,肾病综合征的TNF-α活性与急性肾小球肾炎,过敏性紫瘢肾炎肾病,IgA肾病相比,P<0.001,有显著差异;④肾炎性肾病的TNF-α活性与单纯性肾病比较P<0.001,有非常显著差异。讨论了TNF-α在小儿肾脏疾病的发病作用和监测血清TNF-α水平有助于判定肾脏疾病的病情和预后。
The dynamic changes of serum tumor necrosis factor (TNF-α) activity in 138 children with renal disease were examined and compared with those in 30 normal healthy children. The results showed that the activity of TNF-α in acute stage or renal stage of pediatric kidney disease Significantly increased compared with the normal group, P <0.001, while the recovery period decreased significantly; ② pediatric kidney disease before and after treatment TNF-α activity compared to P <0.001, there was a significant difference; ③ pediatric kidney disease, nephrotic syndrome Compared with acute glomerulonephritis, allergic purpura nephritis and IgA nephropathy, there was a significant difference (P <0.001); ④TNF-α activity of nephritic nephropathy was significantly lower than that of simple nephropathy , There are very significant differences. Discusses the role of TNF-α in the pathogenesis of kidney disease in children and the monitoring of serum TNF-α levels to help determine the condition and prognosis of kidney disease.