论文部分内容阅读
根据曲洛司坦的结构及合成工艺,制备了可能存在的3个有关物质:17?-羟基-4?,5?-环氧雄甾烷并[3,2-c]异噁唑(A)、2-氰基雄甾-2,4-二烯-3,17?-二醇(B)和4?,5?-环氧-2?-氰基-17?-羟基雄甾-3-酮(C),并经MS、1H NMR和13C NMR确证结构,以作为曲洛司坦质量研究的参照物。
According to the structure and synthesis of tralomelus, three possible related substances were prepared: 17-hydroxy-4, 5-epoxyandrostane [3,2-c] ), 2-cyanoandrosta-2,4-diene-3,17-diol (B) and 4,5- epoxy-2’-cyano-17’-hydroxyandrost- Ketone (C), and the structures were confirmed by MS, 1H NMR and 13C NMR as a reference for the quality control of troxerutin.