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目的:探讨冠状动脉造影过程中冠状动脉慢血流(coronary slow flow,CSF)现象的检出率、临床意义及诊治方法。方法:在冠状动脉造影过程中采用多体位投照及观察,并对可疑患者经冠状动脉内注射硝酸甘油200μg后复查造影,对检出冠状动脉慢血流现象者临床资料进行回顾性分析。结果:1 807例行冠状动脉造影患者中共检出慢血流现象85例,检出率4.7%。结合临床观察85例患者均有不同程度的胸痛及心电图ST-T改变。结论:冠状动脉慢血流现象并不罕见,治疗上以能扩张小于200μm血管的双嘧达莫为主要药物,他汀类药物能改善CSF患者微循环,钙离子拮抗剂可能改善冠状动脉的微血管舒张功能,可显著改善CSF患者的血流速度,总体预后良好。
Objective: To investigate the detection rate, clinical significance and diagnosis and treatment of coronary slow flow (CSF) during coronary angiography. Methods: The multi-position projection and observation were performed during coronary angiography. The suspicious patients were retrospectively analyzed by intracoronary injection of 200 μg of nitroglycerin, and the clinical data of the patients with detected coronary artery slow flow were retrospectively analyzed. Results: A total of 857 cases of slow blood flow were detected in 1 807 routine coronary angiography, the detection rate was 4.7%. Combined with clinical observation of 85 patients had varying degrees of chest pain and ECG ST-T changes. CONCLUSIONS: Coronary slow flow is not uncommon and is treated primarily with dipyridamole, which can dilate blood vessels less than 200 μm in diameter. Statins can improve microcirculation in CSF and calcium antagonists may improve coronary vasodilation Function, can significantly improve the blood flow velocity of CSF patients, the overall prognosis is good.