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目的:探讨抑癌基因MT-3在食管鳞癌中的表达及与临床预后的相关性。方法:应用免疫组织化学SABS法检测65例食管鳞癌组织中MT-3表达水平及临床病理的相关性。结果:食管鳞癌组织中MT-3阴性表达为60%(39/65例);与癌旁组织比较,差异有统计学意义(P=0.03)。MT-3表达水平与淋巴结转移、分化程度、浸润程度、TNM分期均明显相关(P=0.001)。多因素统计分析提示MT-3阴性是食管鳞癌预后的独立危险因素(P=0.001)。结论:MT-3阴性表达与肿瘤的复发、转移密切相关。
Objective: To investigate the expression of tumor suppressor gene MT-3 in esophageal squamous cell carcinoma and its correlation with clinical prognosis. Methods: The immunohistochemical SABS method was used to detect the expression of MT-3 in 65 cases of esophageal squamous cell carcinoma and its clinicopathological correlation. Results: The negative expression of MT-3 in esophageal squamous cell carcinoma was 60% (39/65 cases). Compared with the adjacent tissues, the difference was statistically significant (P = 0.03). MT-3 expression was significantly associated with lymph node metastasis, degree of differentiation, degree of infiltration and TNM stage (P = 0.001). Multivariate statistical analysis suggested that MT-3 negative was an independent risk factor for esophageal squamous cell carcinoma prognosis (P = 0.001). Conclusion: The negative expression of MT-3 is closely related to tumor recurrence and metastasis.