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药物使人延年益寿,自古以来为人们所重视。随着科学技术的发展,可应用许多现代化的方法对药物进行筛选,其中测定单胺氧化酶(MAO)的活性尤其引人注目。自帕尼累姆发现了MAO后,引起了生物学家的关注。大量研究发现,在人体衰老过程中某些老年疾病和MAO的活性有一定的关系。1971年洛比森报导了人在45岁以前,MAO活性曲线是平缓上升的。45岁以后则呈直线上升状态,1980年弗勒研究了人脑23个区域,发现MAO有A、B两种构型。其中A型与年龄关系不大,而B型(MAO—B)活性则明显随年龄增长而提高。因而生
Drugs make people live longer, people pay attention to since ancient times. With the development of science and technology, many modern methods can be applied to screen drugs, of which the activity of monoamine oxidase (MAO) is particularly noticeable. After the discovery of MAO by Panilem, it attracted the attention of biologists. A large number of studies have found that certain aging diseases and the activity of MAO in the process of human aging have a certain relationship. In 1971, Lobson reported that before the age of 45, the MAO activity curve increased gently. After 45 years of age was a straight-line rise in 1980, Fleis studied 23 regions of the human brain and found MAO A, B two configurations. Type A was not related to age, while type B (MAO-B) activity was significantly increased with age. Thus born