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近年来,人们对应用生物传感器作各种定量分析的兴趣倍增。在这些生物传感器中,最为常用的是酶电极。目前,人们努力的焦点集中在研制免疫传感器上,并已做了许多试验,包括苯并-15-冠-5-地高克辛(benzo-15-crown-5-cigoxin)抗原-离子载体缀合物的混合体压电晶体,场效应晶体管,涂层导线电极以及Clark氧电极。所有这些用于定量免疫学反应的传感器都遇到了同样的问题,即由于难以分离抗原-抗体复合体,因而需要很长的回复时间。耦合在电极表面上的抗原或抗体因失去活性而使重复性欠佳。为使其在全血清或贫血中发生作用,往往需要进行清洗或使样品高度稀释。Robinson等人通过采用磁性电极而解决了
In recent years, there has been a growing interest in the use of biosensors for various quantitative analyzes. Among these biosensors, enzyme electrodes are the most commonly used. At present, efforts have been focused on the development of immunosensors and many tests have been done including the benzo-15-crown-5-cigoxin antigen-ionophore Compound hybrid piezoelectric crystals, field effect transistors, coated wire electrodes and Clark oxygen electrodes. All of these sensors for use in quantitative immunological reactions encounter the same problem of requiring long recovery times due to the difficulty of isolating the antigen-antibody complex. Antigen or antibody coupled to the electrode surface is less reproducible due to loss of activity. To make it work in whole blood or anemia, it is often necessary to clean or dilute the sample. Robinson et al. Solved the problem by using a magnetic electrode