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目的探讨新的肿瘤标志物ＧＰ８７在老年胃癌及胃癌前病变中表达的情况，从而确定其在上述病变中的应用价值。方法采用ｓＡＢＣ免疫组化染色法对２８３例标本进行染色分析。结果正常胃体、胃窦均为阴性，浅表性胃炎组阳性率为７．１％，明显低于癌症组及癌前病变组（Ｐ＜０．０１）。胃癌组阳性率为６２．０％，明显低于癌前病变各组阳性率（Ｐ＜０．０５），癌旁粘膜组阳性率亦较高，在８０．０％左右。结论新的肿瘤标志物ＧＰ８７在胃癌及胃癌前病变中均有较高表达，特别是在胃癌前病变中的表达更高，故认为ＧＰ８７是检测胃癌前病变较好的肿瘤标志物，可用于胃癌高危人群的普查，筛选出具有明确癌前病变的病人，定期随访、长期追踪，无疑有助于发现早期胃癌。
Objective To investigate the expression of new tumor marker GP87 in elderly patients with gastric cancer and precancerous lesions, so as to determine its application value in these diseases. Methods 283 specimens were stained by sABC immunohistochemical staining. Results The normal gastric body and gastric antrum were negative, and the positive rate in the superficial gastritis group was 7.1%, which was significantly lower than that in the cancer group and the precancerous lesion group (P<0.01). The positive rate of gastric cancer group was 62.0%, which was significantly lower than that of precancerous lesions (P<0.05). The positive rate of paraneoplastic mucosa group was also high, about 80.0%. Conclusion The new tumor marker GP87 is highly expressed in gastric cancer and precancerous lesions, especially in precancerous lesions. It is considered that GP87 is a good tumor marker for detecting precancerous lesions and can be used for gastric cancer. The screening of high-risk populations, screening for patients with precancerous lesions, regular follow-up, long-term follow-up, will undoubtedly help find early gastric cancer.