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目的 探讨S Tn抗原在胃癌及胃癌前病变组织中的表达情况 ,评价S Tn抗原对胃癌的诊断价值。方法 采用免疫组织化学染色法对 10 9例胃癌、70例癌旁粘膜、19例慢性萎缩性胃炎(chronicatrophicgastritis,CAG)、2例慢性浅表性胃炎 (chronicsuperficialgastritis,CSG)、2 8例正常胃粘膜进行染色分析。结果 胃癌组总阳性率为 74 3% ,其中印戒细胞癌阳性率最高为 83 8% ,随着分化程度的降低 ,阳性率愈来愈低。癌旁粘膜阳性率为 84 3% ,明显高于胃癌组 (P <0 0 1)。CAG组阳性率为 73 7% ,CAG伴肠上皮化生 (intestinalmetaplasia,IM)组明显高于CAG伴不典型增生 (atypicalprolif eration ,ATP)组 (P <0 0 1)。CSG组及正常粘膜为阴性。结论 S Tn在胃癌、癌旁粘膜和萎缩性胃炎中均有较高表达 ,其中以癌旁粘膜组表达率最高。伴有IM时S Tn表达更高 ,为 91 6 %。
Objective To investigate the expression of S Tn antigen in gastric cancer and precancerous lesions and evaluate the diagnostic value of S Tn antigen in gastric cancer. Methods Immunohistochemical staining was performed on 109 cases of gastric cancer, 70 cases of paraneoplastic mucosa, 19 cases of chronic atrophic gastritis (CAG), 2 cases of chronic superficial gastritis (CSG), and 28 cases of normal gastric mucosa. Perform staining analysis. Results The positive rate of gastric cancer was 74 3%, and the positive rate of signet ring cell carcinoma was 83.8%. The lower the degree of differentiation, the lower the positive rate was. The positive rate of paraneoplastic mucosa was 84 3%, which was significantly higher than that of gastric cancer group (P <0 01). The positive rate of CAG group was 73.7%, and the CAG with intestinalmetaplasia (IM) group was significantly higher than the CAG with atypical prolifation (ATP) group (P <0 01). The CSG group and normal mucosa were negative. Conclusion S Tn is highly expressed in gastric cancer, paraneoplastic mucosa and atrophic gastritis. The highest expression rate is in the paraneoplastic mucosa. S Tn expression was higher at 91.6% with IM.