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目的 研究单剂欧必亭加地塞米松预防大剂量顺铂化疗所致恶心呕吐的疗效。方法 将 93例接受大剂量顺铂化疗的患者随机分为欧必亭组和枢复宁组 ,分别于第 1天用顺铂前 30min静滴地塞米松 1 0mg ,静注欧必亭 5mg或枢复宁 8mg ,观察两组急性和迟发性恶心呕吐的控制率。 结果 欧必亭组预防急性恶心、呕吐的有效率分别为 97.9%和 95 .8% ,CR率均为 91 .6 % ;预防迟发性恶心、呕吐的有效率均在 80 %以上 ,但CR率偏低 ,有超过一半的患者其迟发性恶心未完全控制。与枢复宁组比较 ,除预防急性恶心的CR率欧必亭组优于枢复宁组外 ,其余指标两组均无显著性差异。结论 单剂欧必亭加地塞米松能有效预防大剂量顺铂化疗所致的急性恶心、呕吐 ,但迟发性恶心、呕吐的完全控制率偏低。
Objective To study the curative effect of single-dose oputibination combined with dexamethasone on preventing nausea and vomiting caused by high-dose cisplatin chemotherapy. Methods Ninety-three patients undergoing high-dose cisplatin chemotherapy were randomly divided into two groups: Euripin group and Shu-Fu-Ning group. On the first day, dexamethasone (10 mg) , To observe the two groups of acute and delayed control of nausea and vomiting. Results The effective rate of Aubinting group in preventing nausea and vomiting was 97.9% and 95.8% respectively, and the CR rates were 91.6%. The effective rate of prevention of delayed nausea and vomiting was over 80% Low, more than half of patients with delayed nausea are not fully controlled. Compared with the Shu Fu Ning group, in addition to the prevention of acute nausea CR rate Ou Bi-Ting group is superior to the Shu-Ning group, the other indicators were no significant difference between the two groups. Conclusions The single-dose oibutidine plus dexamethasone can effectively prevent acute nausea and vomiting caused by high-dose cisplatin chemotherapy, but the complete control rate of delayed nausea and vomiting is low.