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BACKGROUND:?Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease. METHOD:?The medical records of 51 patients with histologically conifrmed solitary necrotic nodule of the liver who received surgical resection at our institution were retrospectively reviewed. RESULTS:?Solitary necrotic nodule of the liver was found mainly in males (68.6%, 35/51), and patients ranged in age from 5 to 69 years with a mean of 45.3. Most of the patients (72.5%) had no signiifcant symptoms, with negative results for the serum tumor markers alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen. The mean diameter of the nodule was 23 mm (range 10-55 mm). Compared with ultrasonographic and computed tomography ifndings, the speciifc features of magnetic resonance imaging were more helpful for differential diagnosis of the disease. CONCLUSIONS:?Solitary necrotic nodule of the liver is a rare nonmalignant lesion, showing no notable symptoms and potential complications. The pathological change of the disease is not signiifcant over a lifetime. Conservative treatment and clinical follow-up are recommended.