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目的:观察益气养血补肾活血中药对体外受精-胚胎移植(IVF-ET)患者应用的功效。方法:对32例拟行IVF-ET的不孕症患者(包括反复IVF移植失败者8例、IVF妊娠后先兆流产者7例、胚胎质量差者7例、卵巢低反应者5例、卵巢功能减退者4例和不明原因不孕者1例)予以益气养血、益肾活血中药治疗,通过B超观察窦卵泡计数(AFC)、胚胎移植时子宫内膜厚度及血基础FSH、LH、E2、P水平等指标,观察用药前、后疗效。结果:予以益气养血补肾活血中药治疗后,有4例(4/8)IVF移植反复失败者成功妊娠;有5例(5/7)IVF妊娠后先兆流产史者继续妊娠;有5例(5/7)胚胎质量差者胚胎质量提高;有3例(3/5)对控制性超促排卵(COH)反应性提高;卵巢功能恢复正常范围者3例(3/4);不明原因不孕者妊娠1例。结论:益气养血补肾活血中药在辅助生殖治疗中发挥了积极作用。
Objective: To observe the efficacy of Yiqi Yangxue Bushen Huoxue Chinese medicine in the application of in vitro fertilization-embryo transfer (IVF-ET). Methods: 32 infertile women who underwent IVF-ET (including 8 cases of IVF-IV failure, 7 cases of threatened abortion after IVF pregnancy, 7 cases of poor embryo quality, 5 cases of low ovarian response, 4 cases of hypothyroidism and 1 case of unexplained infertility) were given Yiqi Yangxue and Yishenhuoxue Chinese herbs. AFC was observed by B-mode ultrasound, endometrial thickness at embryo transfer and basal FSH, LH, E2, P levels and other indicators observed before and after treatment efficacy. Results: Four cases (4/8) IVF failed to succeed in pregnancy after successful treatment with Qi and Nourishing Blood, Reinforcing the Kidney and Activating Blood. In 5 cases (5/7), the history of threatened abortion continued IVF after pregnancy; in 5 cases (5/7) embryos with poor quality embryos; 3 (3/5) increased responsiveness to controlled ovarian hyperstimulation (COH); 3 patients (3/4) had normal ovarian function recovery; unknown causes 1 case of infertility pregnancy. Conclusion: Yiqi Yangxue Bushenhuoxue Chinese medicine plays an active role in assisted reproductive therapy.