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目的:研究喉癌部分切除术(Partial laryngectomy,PL)与仙璐贝药物联用对患者肺部感染的影响。方法:选择2008年3月到2013年3月我院实施PL术式的102例患者,以数字法随机分成观察组(51例)及对照组(51例)。对照组予以常规抗生素及鼻饲饮食,并经雾化吸入等方案治疗;观察组在此基础上另以鼻饲仙璐贝滴剂治疗。治疗10d后,对比两组临床疗效,以及术后肺部感染的情况。随访6个月,比较两组声学参数情况。结果:观察组的疗效显著高于对照组,差异有统计学意义(P<0.05)。观察组与对照组在基频微扰、振幅微扰以及声门噪声值(Normalized noise value,NNE)等方面对比,差异均无统计学意义(均P>0.05)。观察组共计5例患者在治疗过程中产生肺部感染,占比9.80%,显著少于对照组的15例,占比29.41%,差异有统计学意义(P<0.05)。结论:PL手术联合仙璐贝药物治疗喉癌患者疗效显著,可减少肺部感染,值得临床推广。
Objective: To study the effect of partial laryngectomy (PL) combined with radix puerarin on lung infection in patients. Methods: From March 2008 to March 2013, 102 patients who underwent PL procedure in our hospital were randomly divided into observation group (51 cases) and control group (51 cases) by digital method. The control group were given routine antibiotics and nasal feeding diet, and were treated by inhalation and other programs; the observation group on the basis of another nasal feeding fairy Luibei drops treatment. After 10 days of treatment, the clinical efficacy and postoperative pulmonary infection were compared. After 6 months of follow-up, the acoustic parameters of the two groups were compared. Results: The curative effect of the observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). There was no significant difference between the observation group and the control group in terms of fundamental frequency perturbation, amplitude perturbation and NNE (all P> 0.05). A total of 5 patients in the observation group had pulmonary infection during the treatment, accounting for 9.80%, significantly less than 15 cases in the control group, accounting for 29.41%, the difference was statistically significant (P <0.05). CONCLUSION: The effect of PL surgery combined with Opunlu on the patients with laryngeal cancer is significant, which can reduce the pulmonary infection and is worthy of clinical promotion.