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[目的]探讨Hh通路关键分子Shh、Ptch、Gli-1在口腔鳞状细胞癌中的表达及意义。[方法]采用免疫组织化学方法分别检测40例口腔鳞状细胞癌组织和30例口腔黏膜正常组织中Shh、Ptch、Gli-1的表达。[结果]Shh、Ptch、Gli-1在30例正常口腔黏膜中均无表达,在口腔鳞状细胞癌中,Shh、Ptch、Gli-1阳性率分别为62.5%、60.0%和65.0%。Shh、Gli-1的阳性表达与肿瘤大小、淋巴结转移、临床分期相关(P<0.05),Ptch表达与淋巴结转移相关(P﹤0.05)。Spearman等级相关分析显示Shh、Ptch和Gli-1的表达间均存在正相关(rs=0.527、0.406、0.578,P<0.01)。[结论]Shh、Ptch、Gli-1蛋白在口腔鳞状细胞癌组织中均过表达,三者可能通过配体依赖途径被激活并参与口腔鳞癌的发生发展、转移。
[Objective] To investigate the expression of Shh, Ptch and Gli-1 in HH pathway in oral squamous cell carcinoma and its significance. [Methods] Immunohistochemistry was used to detect the expression of Shh, Ptch and Gli-1 in 40 cases of oral squamous cell carcinoma and 30 cases of normal oral mucosa. [Results] Shh, Ptch and Gli-1 were not expressed in all 30 normal oral mucosa. The positive rates of Shh, Ptch and Gli-1 in oral squamous cell carcinoma were 62.5%, 60.0% and 65.0%, respectively. The positive expression of Shh and Gli-1 was correlated with tumor size, lymph node metastasis and clinical stage (P <0.05), and the correlation between Ptch expression and lymph node metastasis (P <0.05). Spearman rank correlation analysis showed that there was a positive correlation between the expression of Shh, Ptch and Gli-1 (rs = 0.527,0.406,0.578, P <0.01). [Conclusion] The Shh, Ptch and Gli-1 proteins are both overexpressed in oral squamous cell carcinoma. The three proteins may be activated by ligand-dependent pathway and participate in the development, metastasis of oral squamous cell carcinoma.