EBOV infects multiple diferent cell types and replicates rapidly in vivo[1].Due to its long ilamentous structure,EBOV is internalized by macropinocytosis ater cell surface receptor binding by the viral glycoprotein(GP).Unlike many other enveloped viruses,EBOV entry process involves multiple steps of traversing of the virion through endosomal vesicle route before its nuclear core is released into cell cytoplasm for replication[2]. EBOV infects multiple diferent cell types and replicates rapidly in vivo [1]. Du to its long ilamentous structure, EBOV is internalized by macropinocytosis ater cell surface receptor binding by the viral glycoprotein (GP) .Unlike many other enveloped viruses, EBOV entry process involves multiple steps of traversing of the virion through endosomal vesicle route before its nuclear core is released into cell cytoplasm for replication [2].