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目的：探讨鼻中隔偏曲矫正术围手术期预防性应用抗生素的临床意义。方法收集鼻中隔偏曲患者180例，随机分成三组，A 组60例，围手术期不用任何抗生素；B 组60例，术前30 min 及术后3 d 内静脉滴注头孢拉定（3．0 g）；C 组60例，术前30 min 及术后3 d 内静脉滴注头孢孟多酯（1．5 g），比较各组术后感染率。结果A 组感染6例（10．0％），B 组感染7例（11．7％），C 组感染5例（8．3％）。三组患者术后感染率差异无统计学意义（χ2＝0．370，P ＝0．831）。结论鼻中隔偏曲矫正术围手术期常规预防性应用抗生素不能降低术后感染发生率，提示围术期可能不必要预防性应用抗生素。“,”Absract:Objective To study the real necessity of antibiotics in septoplasties.Methods A total of 180 patients underwent septoplasty and were randomly divided into group A (n =60),group B (n =60)and group C (n =60). Group A was without antibiotics,group B and group C were respectively given cephradine(3.0 g)or cefamandole (1.5 g)both in the anesthesical induction and post-operatively for 3 days.Results There were 6 cases(10.0%) infected in group A,7 cases(11.7%)infected in group B,and 5 cases(8.3%)infected in group C.The infection rate had no significant difference in the three groups (χ2 =0.370,P =0.831).Conclusion In peri-operative period of sep-toplasty,routine prophylactic use of antibiotics can not reduce the incidence of post-operative infection.