论文部分内容阅读
目的探讨肺透明细胞瘤的临床病理学和免疫组化表型特点、组织起源及鉴别诊断。方法对1例肺透明细胞瘤运用光镜、HE及免疫组化方法分析,并复习相关文献。结果肺透明细胞瘤瘤细胞圆形或椭圆形,胞界清楚,胞浆透明或嗜伊红,无明显核分裂像。免疫组化:HMB-45(+)、CD34(+)、CK(-)、EMA(-)、S-100(-)、Syn(-)、CgA(-),组织化学PAS(+)。结论肺透明细胞瘤是一种较罕见的肿瘤,大多呈良性,坏死罕见,若有坏死,需考虑恶性可能,治疗通常为手术切除。其诊断和鉴别诊断主要依靠组织病理学及免疫组化,熟悉其形态学有利于与其它类似病变如转移的肾透明细胞癌及肺自身发生的透明细胞癌等鉴别。
Objective To investigate the clinicopathological and immunohistochemical features of lung clear cell tumor, its origin and differential diagnosis. Methods One case of clear cell lung tumor was analyzed by light microscope, HE and immunohistochemistry, and the related literatures were reviewed. Results The hyaline tumor cells were round or oval, with clear cytoplasm, clear or eosinophilic cytoplasm, and no obvious mitotic figures. Immunohistochemistry: HMB-45 (+), CD34 (+), CK (-), EMA (-), S-100 (-), Syn (-), CgA (-), histochemistry PAS (+). Conclusions Lung clear cell tumor is a relatively rare tumor, most of which are benign and have rare necrosis. If necrotic, it is necessary to consider the possibility of malignancy. The treatment is usually surgical resection. Its diagnosis and differential diagnosis rely mainly on histopathology and immunohistochemistry, familiar with its morphology is conducive to other similar diseases such as metastatic renal clear cell carcinoma and the lung itself, the occurrence of clear cell carcinoma and other identification.