锰是人体必需的微量元素,而长期慢性接触高浓度锰可引起麻痹震颤,肌肉张力失常为特征的锥体外系损伤的帕金森病(Parkinson’sdisease,PD)症状。PD及慢性锰中毒有许多相似之处,如锥体外系变性,多巴胺耗竭,能量代谢,自由基与兴奋性氨基酸及钙离子紊乱有关。近年来老年特发性PD发病 Manganese is an essential trace element of the human body, and long-term chronic exposure to high concentrations of manganese causes Parkinson’s disease (PD) symptoms of extrapyramidal lesions characterized by paralytic tremor and muscular tension disorders. PD and chronic manganese poisoning have many similarities, such as extrapyramidal degeneration, dopamine depletion, energy metabolism, free radicals and excitatory amino acids and calcium disorders related. In recent years, the incidence of idiopathic PD in the elderly