Ⅰ型糖尿病人可伴发手关节活动障碍(手关节病),发生率约3%—30%,但也见于Ⅱ型糖尿病人。其机制为高血糖引起结缔组织病变、关节周围胶原组织改变,产生手关节活动障碍。伴有微血管病变的糖尿病人中,上述病变更常见。作者发现某些Ⅰ型糖尿病合并有手关节病的妇女易患无痛性乳房纤维性肿块及甲状腺疾患。 作者在88例Ⅰ型糖尿病女患者中(25～40岁),发现伴有乳房肿块者12例,糖尿病程8—30年。除 Type 1 diabetes may be associated with hand-joint dysfunction (hand joint disease), the incidence of about 3% -30%, but also found in type II diabetes. The mechanism of hyperglycemia caused by connective tissue lesions, joint tissue around the collagen changes, resulting in hand movement disorders. Diabetic patients with microvascular disease, the above lesions are more common. The authors found that women with type 1 diabetes and hand joint disease were predisposed to painless breast fibrosis and thyroid disorders. The authors of 88 cases of type I diabetic female patients (25 to 40 years old), found with breast lumps in 12 cases, diabetes duration of 8 to 30 years. except