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目的探讨早期应用纳络酮对急性重型脑梗死近远期的疗效。方法对51例重型脑梗死病人随机分成纳络酮(NLX)治疗组(n=26)和对照组(n=25),观察治疗早期病人颅内压、头颅CT脑水肿变化、近远期疗效,进行统计学分析。结果病后2周内NLX组病人颅内压显著升高和重度脑水肿者较对照组明显减少(P<0.05)。NLX组治疗2周后意识转清醒率(34.6%)高于对照组的(20%)(P<0.05)。病后6个月恢复良好率显著高于对照组,重残率明显减少(P<0.05),死亡率明显下降(P<0.01)。结论早期大剂量运用纳络酮可以降低重型脑梗死病人颅内压的升高幅度,缩短昏迷时间,降低病残率,促进病人神经功能恢复。
Objective To investigate the effect of early application of naloxone on short-term and long-term acute cerebral infarction. Methods 51 patients with severe cerebral infarction were randomly divided into two groups: naloxone (n = 26) and control group (n = 25). The changes of intracranial pressure and CT brain edema were observed in the early stage of treatment. , For statistical analysis. Results The patients with NLX had significantly increased intracranial pressure and severe brain edema in the NLX group within 2 weeks after operation (P <0.05). After 2 weeks of treatment in NLX group, the consciousness-to-wake rate (34.6%) was higher than that in the control group (20%) (P <0.05). The good rate of recovery after 6 months was significantly higher than that of the control group (P <0.05), and the mortality rate decreased significantly (P <0.01). Conclusion Early high-dose naloxone can reduce the increase of intracranial pressure in patients with severe cerebral infarction, shorten the coma time, reduce the morbidity and promote the recovery of neurological function.