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目的:研究不同类型缺血性心脑血管病患者的血浆同型半胱氨酸水平的变化情况,以及观察同型半胱氨酸与其他传统危险因素影响关系。方法:利用全自动生化仪检测本院103例心脑血管病患者(45例脑梗死患者、33例冠心病患者和25例TIA患者)和由56例健康体检者构成的对照组的血浆同型半胱氨酸(Hcy)水平,对Hcy水平与缺血性心脑血管病的相关性以及与其他传统危险因素的关系分析。结果:缺血性心脑血管病患者的Hcy水平高于正常对照组(P<0.05),脑梗死、冠心病和TIA患者的Hcy水平均高于正常对照组(P<0.05),不同类型患者间的Hcy水平没有明显差异,有无传统危险因素的Hcy水平无显著影响(P>0.05)。结论:Hcy水平变化可以作为诊断预防缺血性心脑血管疾病的一种手段,它可能是影响缺血性心脑血管的独立因素。
Objective: To study the changes of plasma homocysteine levels in patients with different types of ischemic cardiovascular diseases and to observe the relationship between homocysteine and other traditional risk factors. Methods: Plasma homoplasia of 103 patients with cardiovascular and cerebrovascular diseases (45 patients with cerebral infarction, 33 patients with coronary heart disease and 25 TIA patients) and control group consisting of 56 healthy subjects were detected by automatic biochemical analyzer. Cystine (Hcy) levels, Hcy levels and ischemic cardiovascular and cerebrovascular disease and other traditional risk factors and the relationship analysis. Results: The Hcy level in patients with ischemic cardiovascular disease was higher than that in the normal control group (P <0.05). The levels of Hcy in cerebral infarction, coronary heart disease and TIA patients were higher than those in the normal control group (P <0.05) There was no significant difference between Hcy levels and Hcy levels with or without traditional risk factors (P> 0.05). Conclusion: The change of Hcy level can be used as a tool to diagnose ischemic cardiovascular and cerebrovascular diseases. It may be an independent factor affecting ischemic cardiovascular and cerebrovascular diseases.