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目的评估中晚期前列腺癌患者的综合治疗效果。方法对1995年1月-2004年6月收治的132例中晚期前列腺癌患者行经尿道前列腺切除术+双侧睾丸切除术,术后口服氟他胺(250 mg,3次/日)综合治疗。结果经尿道前列腺切除后患者排尿困难、血尿症状明显改善,血PSA由(70.8±50.6)ng/mL下降至(38.9±28.1)ng/mL;48例术前发现有骨转移者,术后3个月35例行ECT扫描,均提示骨转移灶减少、缩小,浓集影部分变淡,46例骨关节疼痛减轻;12例患者术后1-2年出现PSA升高,全身骨转移灶加重,病情加重死亡。结论经尿道前列腺切除术+双侧睾丸切除术+术后口服氟他胺的综合方案,治疗中晚期前列腺癌疗效较好。
Objective To evaluate the comprehensive treatment of advanced prostate cancer patients. Methods One hundred and thirty-two patients with advanced prostate cancer undergoing transurethral resection of the urethra and bilateral orchiectomy were enrolled from January 1995 to June 2004. The patients were treated with oral flutamide (250 mg, 3 times daily) after operation. Results After transurethral resection of the prostate, dysuria occurred and the symptoms of hematuria and urine were significantly improved. The blood PSA level decreased from (70.8 ± 50.6) ng / mL to (38.9 ± 28.1) ng / mL. 48 patients had bone metastases and 3 A month 35 ECT scan, all prompted bone metastases to reduce, narrow, part of the concentration of light fades, 46 cases of joint pain relief; 12 cases of patients with 1-2 years after the emergence of elevated PSA, systemic bone metastases increased , The disease aggravated death. Conclusion Transurethral resection of the prostate + bilateral orchiectomy + postoperative oral flutamide comprehensive program for the treatment of advanced prostate cancer better effect.