POF(卵巢早衰)是继发性闭经的常见原因之一,一般被认为是高促性腺激素性闭经,通常发生于40岁以下的妇女。可由某些常染色体异常、盆腔放射、化疗等引起,极少数是与自身免疫有关。患者多以闭经、不孕及低雌激素引起的症状就诊。自1985年3月～1987年6月在我院妇科内分泌专科门诊就诊的闭经妇女中,诊断为POF 者21人,现报告如下: POF (premature ovarian failure) is one of the common causes of secondary amenorrhea and is generally considered to be highly gonadal-stimulated amenorrhea, which usually occurs in women under 40 years of age. May be caused by some autosomal abnormalities, pelvic radiation, chemotherapy, etc., very few are related to autoimmunity. Patients with amenorrhea, infertility and low estrogen-induced symptoms of treatment. From March 1985 to June 1987 in our hospital gynecological endocrine specialist clinic amenorrhea women, the diagnosis of POF were 21, are as follows: