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本文对血卟啉光敏疗法治疗恶性肿瘤中与治疗效果有关的几个因素——光功率、光剂量、温度——进行了细胞和动物实验研究。结果表明,血卟啉光敏反应的程度和对癌细胞的杀伤效果取决于辐照的光剂量而不是光功率,这与光敏反应的机理相符。但在实际治疗中,若采用较大的光辐照功率,会引起肿瘤内的温升,当超过41.5℃的阈值温度后,高温与光敏反应有杀伤癌细胞的协同作用。根据动物实验的结果,在应用血卟啉光敏疗法治疗恶性肿瘤中,采用200~300mW/cm~2光功率密度的光辐照,最能利用高温的协同作用,达到好的效果。
In this paper, several factors related to the therapeutic effect of hematoporphyrin phototherapy in the treatment of malignant tumors—optical power, light dose, and temperature—were studied in cell and animal experiments. The results showed that the degree of photosensitivity of hematoporphyrin and the killing effect on cancer cells depend on the dose of light but not the optical power, which is consistent with the mechanism of photoreaction. However, in actual treatment, if a larger light irradiation power is used, it will cause a temperature rise in the tumor. When the threshold temperature exceeds 41.5° C., the high temperature and the photosensitive reaction have a synergistic effect of killing the cancer cells. According to the results of animal experiments, in the application of hematoporphyrin photosensitive therapy for the treatment of malignant tumors, light irradiation with an optical power density of 200 to 300 mW/cm~2 can best utilize the synergy of high temperature to achieve good results.