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目的分析纳洛酮联合复方丹参注射液对新生儿缺氧缺血性脑病临床效果。方法选择2010年9月~2011年6月我院收治的90例缺氧缺血性脑病患儿,并随机分成常规组与实验组,每组各45例。常规组给予常规治疗,实验组在此基础上给予纳洛酮联合复方丹参注射液治疗。比较两组临床治疗效果及后遗症发生率情况。结果比较治疗前两组患儿神经行为测定(NBNA)评分,无明显差异,因而不具有统计学意义标准(P>0.05),治疗后实验组NBNA评分明显高于常规组,因而有统计学意义(P<0.05)。实验组、常规组治疗总有效率分别为95.5%,71.1%;后遗症发生率分别为8.8%,17.7%,比较两组治疗总有效率及后遗症发生率,实验组明显优于常规组,因而有统计学意义(P<0.05)。结论对于新生儿缺氧缺血性脑病,采用纳洛酮联合复方丹参注射液治疗,疗效确切,安全性高,且后遗症发生率低,值得推广。
Objective To analyze the clinical effect of naloxone combined with Salvia miltiorrhiza on neonatal hypoxic-ischemic encephalopathy. Methods From September 2010 to June 2011, 90 children with hypoxic-ischemic encephalopathy admitted to our hospital were randomly divided into routine group and experimental group with 45 cases in each group. The conventional group was given routine treatment, and the experimental group was given naloxone combined with compound Salvia miltiorrhiza injection on this basis. The clinical efficacy and the incidence of sequelae were compared between the two groups. Results Compared with the NBNA score of the two groups, there was no significant difference between the two groups (P> 0.05). After treatment, the NBNA score of the experimental group was significantly higher than that of the conventional group (P <0.05). The total effective rates of experimental group and conventional group were 95.5% and 71.1% respectively. The incidence of sequelae was 8.8% and 17.7% respectively. The total effective rate and the incidence of sequela were compared between the two groups, and the experimental group was significantly better than the conventional group Statistical significance (P <0.05). Conclusion For neonatal hypoxic-ischemic encephalopathy, the use of naloxone combined with compound Salvia injection treatment, the exact effect, high safety, and the incidence of sequelae is low, it is worth promoting.