作者初步探讨了成年雌性大鼠(150 g)慢性摄入p,p′-DDT和r-HCH后对脑的不同部位毒蕈碱受体的影响,发现这种影响对脑的某些部位具有选择性。动物随机分为三组:正常饲料组、400μgp,p′-DDT/g饲料组,400μg r-HCH/g饲料组。动物自由进食,两个月后断头处死,取出脑组织,将大脑皮层、间脑、小脑和脑桥分别制成匀浆,用以测定[~3H]quinuclidinyl benzylate([~3H]ONB)对毒蕈碱受体的结合,同时用气相色谱法测定染毒动物脑各部位中两种杀 The authors initially explored the effects of chronic ingestion of p, p’-DDT and r-HCH on muscarinic receptors in different parts of the brain in adult female rats (150 g) and found that this effect had some effects on certain parts of the brain Selective. Animals were randomly divided into three groups: normal feed group, 400μgp, p’-DDT / g feed group, 400μg r-HCH / g feed group. The animals were allowed to eat freely and were sacrificed two months later by decapitation. The brain tissue was removed and the cortex, diencephalon, cerebellum and pons were homogenized respectively to measure the toxicity of [~ 3H] quinuclidinyl benzylate ([~ 3H] ONB) The binding of muscarinic receptors was determined by gas chromatography