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目的观察龙血竭总酚滴丸对大鼠局灶性脑缺血的保护作用。方法采取线栓法制造大鼠右侧大脑中动脉栓塞模型。将大鼠分为假手术组、模型组、对照组、龙血竭原料药组及龙血竭总酚滴丸高、中、低剂量组,各给药组ig给药,qd,连续4 d,第5天上午继续给药1次,1 h后进行手术,术后24 h时,对各组大鼠分别进行神经功能评分,处死并测定梗死体积。结果龙血竭总酚滴丸各剂量组均可显著降低大鼠脑缺血后神经功能的评分(P<0.05或P<0.01),缩小脑梗死体积(P<0.05或P<0.01)。结论龙血竭总酚滴丸对大鼠局灶性脑缺血损伤具有较好的保护作用。
Objective To observe the protective effect of Longdexu Total Phenolic Droplets on focal cerebral ischemia in rats. Methods The right middle cerebral artery occlusion model was established by thread occlusion. The rats were divided into sham operation group, model group, control group, DRG drug group and DRG TPH group, high, medium and low dose groups. Each group received ig administration for qd for 4 days On the fifth day, the drug was administered once a day and surgery was performed after 1 hour. At 24 hours after operation, the neurological function scores of the rats in each group were respectively evaluated and sacrificed. The infarct volume was measured. Results The results showed that each group of DRG can significantly reduce the neurological deficit score (P <0.05 or P <0.01) and decrease the infarct volume (P <0.05 or P <0.01). Conclusion Dragon Blood Total Phenolic dripping pills have a good protective effect on focal cerebral ischemia injury in rats.