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神经干细胞(ＮＳＣ)是一种具有自我更新能力、能分化产生神经系细胞的种子细胞,目前已能分离、培养和纯化ＮＳＣ,但如何诱导、调控其向功能(目的)神经细胞分化尚未解决。在果蝇的神经系统发育研究中发现一种抑制性信号传导通路－Ｎｏｔｃｈ信号系统。进一步的研究发现Ｎｏｔｃｈ同源分子的表达很广泛,在哺乳动物中Ｎｏｔｃｈ信号对神经干细胞的增殖和分化也起着非常重要的调控作用,在哺乳动物ＣＮＳ发育中扮演了关键角色。通过Ｎｏｔｃｈ信号的改变有可能调控神经干细胞向神经功能细胞的分化。
Neural stem cells (NSCs), a kind of self-renewing seed cells that can differentiate into neural cells, have been isolated, cultured and purified. However, how to induce and regulate neural stem cells (NSCs) to function (purpose) has not been solved yet. In Drosophila neurogenesis research found a inhibitory signaling pathway -Notch signal system. Further study found that Notch homologous molecules are widely expressed. Notch signaling plays a very important regulatory role in the proliferation and differentiation of neural stem cells in mammals and plays a key role in mammalian CNS development. Through the change of Notch signal, it is possible to regulate the differentiation of neural stem cells into neuronal cells.