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地拉韦定(delavirdine)是由美国Pharmacia &Upjohn公司研制的非核苷HIV-1逆转录酶抑制剂(NNRTIs),临床与其它抗HIV药联合使用,用于治疗获得性免疫缺陷综合征。1-(5-硝基吲哚-2-羰基)-4-[3-(1-甲基乙胺基)-2-吡啶基]哌嗪(1)是其重要中间体。文献以5-硝基吲哚-2-羧酸(2)
Delavirdine, a non-nucleoside HIV-1 reverse transcriptase inhibitor (NNRTIs) developed by the United States Pharmacia & Upjohn, is clinically used in combination with other anti-HIV drugs for the treatment of acquired immunodeficiency syndrome. 1- (5-Nitroindole-2-carbonyl) -4- [3- (1-methylethylamino) -2-pyridyl] piperazine (1) is an important intermediate thereof. References to 5-nitroindole-2-carboxylic acid (2)