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本文报告二例髓母细胞瘤放疗后产生甲状腺新生物的病例:例一为28岁的白人妇女,1963年10月手术切除左侧小脑髓母细胞瘤。术后6周内全脑照射 4040伦琴,同时对脊髓照射4420伦琴。1977年5月因髓母细胞瘤局部复发死亡。尸解发现甲状腺左叶有一4厘米大小分化好的乳头状腺癌,并有甲状腺旁数个淋巴结转移。例二为4岁的黑人女孩,1959年6月从左侧小脑切除4～5厘米的髓母细胞瘤。术后三周内对全中枢神经系统照射3000伦琴。1976年10月发现甲状腺出现结节,甲状腺次全切除术后标本证实为从数毫米至4厘米不等的滤泡状腺瘤,并可见特殊的增生上皮。关于童年头颈部放射与甲状腺新生物间的关系,
This article reports two cases of thyroid neoplasms after radiotherapy for medulloblastoma: a white 28-year-old woman. In October 1963, she underwent surgical resection of left cerebellar medulloblastoma. In the whole brain, 4040 roentgens were irradiated within 6 weeks after operation, and 4,420 roentgens were irradiated to the spinal cord. May 1977 died of local recurrence of medulloblastoma. Autopsy revealed that the left lobe of the thyroid gland had a well-differentiated papillary adenocarcinoma of 4 cm in size and several metastatic lymph nodes. Case 2 is a 4-year-old black girl. In June 1959, 4 to 5 cm of medulloblastoma was removed from the left cerebellum. In the three weeks after surgery, the whole central nervous system was irradiated with 3,000 roentgens. In October 1976, nodules were found in the thyroid gland. After subtotal thyroidectomy, the specimens were confirmed to be follicular adenomas ranging from a few millimeters to 4 centimeters, and special hyperplastic epithelium was visible. The relationship between childhood head and neck radiation and new thyroid glands,