近年来,国外许多学者应用器官培养方法研究气管上皮癌变及肺癌的病因等问题,然而由于对离体和在体环境之间差异的影响认识不足,观察部位及判定指标尚未统一;观察方法较为单一,从而影响了这方面问题的深入研究,为了提供吸烟因素与肺癌发生关系的实验性依据并探求所存在的问题,本文研究了卷烟浓缩物中性级分对金地鼠离体培养气管上皮的影响,此类研究国内尚未见报导。 In recent years, many foreign scholars use organ culture methods to study the carcinogenesis of tracheal epithelium and the etiology of lung cancer. However, due to lack of understanding of the differences between in vitro and in vivo environment, the observation sites and indicators have not been unified; the observation method is rather single In order to provide an experimental basis for the relationship between smoking factors and lung cancer and to explore the existing problems, this paper studies the effects of the neutral fraction of cigarette concentrates on the tracheal epithelium in vitro culture of golden hamsters Such studies have not been reported in China.