论文部分内容阅读
在制备壳聚糖衍生物N,N,N-三甲基壳聚糖盐酸盐(TMC)的基础上,通过将两种性质相反的电解质溶液进行共混,制备了一种新型的TMC/CMC(羧甲基壳聚糖)纳米载药颗粒体系。用激光散射仪和透射电镜表征了空白颗粒和载药颗粒的粒径、粒径分布、Zeta电位和形态结构。载药体系纳米颗粒的粒径在200~600 nm范围,表面可带正或负电荷,且Zeta电位具有可调性。研究表明:牛血清蛋白(BSA)的包封率与起始的TMC、BSA浓度相关;纳米载药颗粒对BSA的释放表现为,先爆释而后缓释并可保持40 h以上的释放。
Based on the preparation of the chitosan derivatives N, N, N-trimethyl chitosan hydrochloride (TMC), a new type of TMC / TMC was prepared by blending two kinds of electrolytes with opposite properties. CMC (carboxymethyl chitosan) nanoparticles drug delivery system. The particle size, particle size distribution, Zeta potential and morphological structure of blank and drug-loaded particles were characterized by laser light scattering and transmission electron microscopy. The particle size of the drug-loaded nanoparticles is in the range of 200-600 nm, the surface can be positively or negatively charged, and the Zeta potential is adjustable. The results showed that the entrapment efficiency of bovine serum albumin (BSA) was related to the initial concentration of TMC and BSA. The release of BSA by nano-drug-loaded particles showed that the release of BSA was followed by sustained release and sustained release for more than 40 h.