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以津白Ⅰ号同系小鼠作为实验动物。除生理盐水对照组外,分三组(卡介苗组、卡介苗瘤组织匀浆混合液组、卡介苗瘤组织匀浆混合液加胸腺素组)进行免疫。免疫一周后用悬液法接种前胃鳞状细胞癌,观察肿瘤生长情况。结果显示:1)卡介苗无明显抑瘤效果;2)卡介苗瘤组织匀浆混合液有一定的抑瘤效果,但效果不稳定;3)卡介苗瘤组织匀浆混合液加胸腺素,当短期应用胸腺素时,无明显效果,但当长期应用胸腺素时,则表现出明显的效果。一般地说,胸腺素能促进前T细胞转变为T细胞,增加T细胞的量;特殊地说,在卡介苗瘤组织匀浆混合液免疫的同时应用胸腺素,推测还能改变T细胞的质的组成,增加特异的针对该肿瘤的T细胞的量。
Jinbai I synoviy mice were used as experimental animals. In addition to the saline control group, three groups (BCG, BCG homogenate mixture, and BCG mixed homogenate plus thymosin) were immunized. One week after immunization, the gastric squamous cell carcinoma was inoculated with a suspension method to observe the growth of the tumor. The results showed that: 1) BCG had no significant anti-tumor effect; 2) BCG mixed homogenate had certain anti-tumor effect, but the effect was unstable; 3) BCG homogenate mixed with thymosin when short-term use of thymus At the same time, there was no obvious effect, but when the thymosin was applied for a long time, it showed a significant effect. In general, thymosin can promote the conversion of pre-T cells to T cells and increase the amount of T cells; in particular, the use of thymosin in combination with immunization with the homogenate mixture of BCG tumors presumably also alters the quality of T cells. The composition increases the amount of specific T cells directed against the tumor.