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维生素D(VD)不仅在调节骨和矿物质代谢中起作用,而且还参与身体内许多基本的代谢过程。 VD起作用的生化基础,以前一直不太清楚,直到60年代随着发现了维生素D是作为调节钙的类固醇激素的前体,1,25(OH)_2胆钙化醇在起作用才开始理解了它的作用原理。VD的名称是一个误称,胆钙化醇按普遍公认的必需营养素需要来说并不能算作一个维生素。因为它可在皮肤中经光合作用而合成,暴露于阳光充足,可产生足够的维生素D。在1970年前后,对它的研究重点集中在两个方面,一是阐明调节肾脏生产1,25(OH)_2D_3的方式,二是弄清它对靶器官的激素样作用。肠中钙的吸收直接受到1,25
Vitamin D (VD) not only plays a role in regulating bone and mineral metabolism, but also participates in many basic metabolic processes in the body. The biochemical basis for the function of VD has not been known until the 1960s, when vitamin D was discovered as a precursor of steroid hormones that regulate calcium, 1,25(OH)2cholecalciferol only began to understand its role. Its function principle. The name of VD is a misnomer, and cholecalciferol cannot be counted as a vitamin in terms of universally recognized essential nutrient requirements. Because it can be synthesized in the skin through photosynthesis, exposure to sunlight can produce enough vitamin D. Before and after 1970, its research focused on two aspects. One was to clarify the way to regulate kidney production of 1,25(OH)_2D_3, and the other was to clarify its hormone-like effects on target organs. Intestinal calcium absorption is directly affected by 1,25