论文部分内容阅读
目的观察不同抗生素对新生儿肠道菌群的影响。方法将呼吸道感染患儿60例随机分为2组各30例,观察组给予氨苄西林联合青霉素治疗,对照组给予头孢哌酮钠治疗,治疗后比较2组腹泻发生率及患儿肠道菌群变化。结果观察组腹泻发生率26.7%(8/30)低于对照组的53.3%(16/30),2组腹泻发生率比较差异有统计学意义(P<0.05)。观察组治疗后肠杆菌科细菌显著增多(P<0.05),其他细菌无明显变化(P>0.05)。对照组治疗后酵母菌增多(P<0.05),其他菌种显著减少(P<0.05)。结论两类抗生素均会造成患儿肠道菌群失调,但氨苄西林联合青霉素所造成的菌群失调低于头孢哌酮钠。
Objective To observe the effect of different antibiotics on neonatal intestinal microflora. Methods 60 cases of children with respiratory tract infection were randomly divided into two groups of 30 cases. The observation group was treated with ampicillin combined with penicillin. The control group was treated with cefoperazone sodium. The incidence of diarrhea and intestinal microflora in the two groups were compared after treatment. Results The incidence of diarrhea was 26.7% (8/30) in the observation group and 53.3% (16/30) in the control group respectively. The incidence of diarrhea in the two groups was significantly different (P <0.05). The number of Enterobacteriaceae in the observation group increased significantly (P <0.05), but no significant changes in other bacteria (P> 0.05). The number of yeast in the control group increased (P <0.05), and the other strains decreased significantly (P <0.05). Conclusion Both antibiotics cause intestinal flora dysfunction in children, but ampicillin combined penicillin caused less flora than cefoperazone sodium.