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Two novel compounds (4a and 4b) were obtained by the association of 2,2,4-trimethyl-3-hydroxy-5-cyclohexenecarboxylate with (S)-isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via group was selectively protected with diazomethane. All the products were characterized via 1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP-Ⅳ inhibitor.