论文部分内容阅读
目的:研究膜型基质金属蛋白酶-1(MT1-MMP)在上皮性卵巢肿瘤组织中的表达及临床意义。方法:应用免疫组化EnVision法检测40例上皮性卵巢癌(A组)、20例交界性上皮性卵巢肿瘤(B组)、20例良性上皮性卵巢肿瘤(C组)和20例正常卵巢组织(D组)中MT1-MMP的表达和预后。结果:MT1-MMP在上皮性卵巢癌中的阳性率(95%)显著高于良性卵巢肿瘤(45%)和正常卵巢(35%),A组中的强阳性率(77.5%)显著高于B组(30%)、C组(10%)和D组(10%)(P<0.05);D组中未绝经者的阳性率(66.7%)显著高于绝经者(9.1%)(P<0.05);晚期上皮性卵巢癌中的强阳性率(100%)显著高于早期的强阳性率(52.6%)(P<0.05);中低分化(G2～G3级)上皮性卵巢癌中的强阳性率(86.7%)显著高于高分化(G1级)的强阳性率(50%)(P<0.05);有淋巴转移的上皮性卵巢癌中的强阳性率(94.4%)显著高于无淋巴转移组的强阳性率(63.6%)(P<0.05)。在单因素生存分析中,A组中MT1-MMP的表达与患者预后不良有关;B组中MT1-MMP表达强阳性组(++～+++)的复发率(66.7%)显著高于MT1-MMP表达阴性～弱阳性组(-～+)的复发率(7.1%)(P<0.05)。结论:MT1-MMP可能参与卵巢的正常生理功能,它的异常高表达在上皮性卵巢癌的浸润、转移和交界性上皮性卵巢肿瘤的复发中起了重要作用,MT1-MMP的表达与患者预后不良有关。
Objective: To investigate the expression and clinical significance of membrane-type matrix metalloproteinase-1 (MT1-MMP) in epithelial ovarian tumors. Methods: 40 cases of epithelial ovarian cancer (group A), 20 cases of borderline epithelial ovarian tumor (group B), 20 cases of benign epithelial ovarian tumor (group C) and 20 cases of normal ovarian tissue (Group D) MT1-MMP expression and prognosis. Results: The positive rate of MT1-MMP in epithelial ovarian cancer (95%) was significantly higher than that in benign ovarian tumor (45%) and normal ovary (35%). The positive rate of MT1-MMP in group A was significantly higher than that in group A The positive rate of non-menopausal group (66.7%) in group D was significantly higher than that in menopausal group (9.1%) (P <0.05) <0.05). The strong positive rate (100%) in advanced epithelial ovarian cancer was significantly higher than that in early stage (52.6%) (P <0.05). In moderately differentiated (G2 ~ G3) epithelial ovarian cancer (86.7%) was significantly higher than that of highly differentiated (G1) (50%) (P <0.05). The strong positive rate (94.4%) in lymphatic metastatic epithelial ovarian cancer was significantly higher Strong positive rate in non-lymphatic metastasis group (63.6%) (P <0.05). In univariate survival analysis, the expression of MT1-MMP in group A was related to the poor prognosis of patients. The recurrence rate (66.7%) of group B with strong MT1-MMP expression was significantly higher than that of MT1 The recurrence rate (-%) of negative-weakly -MPMP expression group (7.1%) (P <0.05). Conclusion: MT1-MMP may participate in the normal physiological function of ovary. Its abnormally high expression plays an important role in the invasion and metastasis of epithelial ovarian cancer and the relapse of borderline epithelial ovarian tumors. The expression of MT1-MMP and prognosis Bad about.