受体不可逆结合配基可用于研究受体和受体后环节或生理效应间的偶联,受体代谢、受体亚型及受体纯化等;经放射性同位素标记后可作为亲和标记探针,研究受体结构功能间的关系、分布和定位而受到重视。但对β肾上腺素受体(βAR)不可逆结合配基报道极少。BAlpM为Ⅰ和Ⅱ的混合物,二者有同等的生物活性,是Pitha等最近合成的一 Receptor irreversible binding ligands can be used to study the coupling between the receptor and the posterior aspect of the receptor or physiological effects, receptor metabolism, receptor subtypes and receptor purification; can be used as affinity tagging probe after radioisotope labeling , Study the relationship between receptor structure and function, distribution and positioning of attention. However, β-adrenergic receptor (βAR) irreversible binding ligand reported very little. BAlpM is a mixture of Ⅰ and Ⅱ, the two have the same biological activity, Pitha and other recently synthesized one