论文部分内容阅读
研究抗癫痫药物常用物理方法(如电休克或声刺激)或化学药品引起动物急性惊厥发作,这些方法的优点,观察指标明确,简便易行,缺点,惊厥发作维持时间暂短,只用于急性实验。慢性实验性癲痫模型,是研究抗癲痫药的重要方法,它可用来系统观察药物的治疗效果。国内未见报道,国外常用钴、铝和青霉素等注入狒狒、猴和猫等动物脑的不同部位,形成慢性模型,但上述药物对家兔均不敏感。我们发现向家兔脑室内注射微量的铁剂,可形成典型的慢性实验性癲痫模型,为今后研究抗癲痫药物提供了一个较好的方法,现简报如下。
The study of antiepileptic drugs commonly used physical methods (such as electroshock or acoustic stimulation) or chemicals caused acute seizures in animals, the advantages of these methods, the observation of a clear, easy to use, shortcomings, seizures to maintain short duration of time, only for acute experiment. Chronic experimental epilepsy model, is an important method to study antiepileptic drugs, it can be used to systematically observe the therapeutic effect of drugs. No reports have been reported in China. Cobalt, aluminum and penicillin are often injected into different parts of the brain of baboons, monkeys and cats to form a chronic model. However, these drugs are not sensitive to rabbits. We found that intra-ventricular injection of iron to rabbits can form a typical experimental model of chronic epilepsy, for the future study of antiepileptic drugs provide a better method, are briefings are as follows.