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由于化学合成的迅速发展,探索快速简易测定急性毒性的方法,对毒理学更好地为生产服务有重要意义。为了快速测定工业中有害物质的急性毒性,本文初步探讨了求得“大致致死量”的方法。实验用小鼠。各受试物质配制成连续的5～6挡剂量,组距保持在2/3(或3/2)左右。剂量选择按同系物的毒性或文献资料加以估计,有时先用500毫克/公斤和50毫克/公斤的剂量,作预试后确定。各挡剂量分别投药给2～3只小鼠。腹腔注射及灌胃均按10
Due to the rapid development of chemical synthesis, it is of great significance to explore the rapid and simple method for the determination of acute toxicity which is better for toxicology to produce services. In order to quickly determine the acute toxicity of harmful substances in the industry, this article initially explored the method of “approximate lethal dose”. Experimental mice. Each test substance is formulated into a continuous dose of 5 ~ 6 block, group spacing maintained at 2/3 (or 3/2) or so. Dose selection is assessed on the basis of homologue toxicity or literature, sometimes at doses of 500 mg / kg and 50 mg / kg as pre-test determinations. Each block dose were administered to 2 to 3 mice. Intraperitoneal injection and gavage are 10