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目的探讨慢性阻塞性肺疾病继发肺部真菌感染患者的临床特征及其危险因素。方法回顾性分析42例慢性阻塞性肺疾病继发肺部真菌感染患者的临床资料。结果慢性阻塞性肺疾病继发肺部真菌感染患者临床表现无特异性,胸部X线检查以支气管肺炎多见,病原菌以白色念珠菌为主。广谱高效抗生素、糖皮质激素的应用,低蛋白血症以及高龄是继发真菌感染的主要危险因素。结论降低慢性阻塞性肺疾病继发真菌感染率的主要方法是合理使用抗生素和糖皮质激素,预防医源性感染,提高患者的免疫力。
Objective To investigate the clinical characteristics and risk factors of patients with pulmonary fungal infection secondary to chronic obstructive pulmonary disease. Methods The clinical data of 42 patients with pulmonary fungal infection secondary to chronic obstructive pulmonary disease were retrospectively analyzed. Results Chronic obstructive pulmonary disease secondary to pulmonary fungal infection in patients with nonspecific clinical manifestations, chest X-ray examination to bronchopneumonia more common pathogens to Candida albicans. Broad-spectrum antibiotics, glucocorticoid use, hypoproteinemia, and advanced age are the major risk factors for secondary fungal infections. Conclusion The main method to reduce the secondary fungal infection rate in chronic obstructive pulmonary disease is rational use of antibiotics and glucocorticoids to prevent iatrogenic infection and improve the patient’s immunity.