祛痰剂可分为反射性祛痰剂、刺激性祛痰剂、黏液调节剂、黏液溶解剂和黏液促排剂。传统的黏液调节剂主要有溴已新和羧甲司坦等,肺内感觉神经肽释放抑制剂、速激肽拮抗剂、介质合酶抑制剂和MUC基因抑制剂是目前研究得较多的新型黏液调节剂,本文主要讨论上述新型黏液调节剂的分子生物学研究进展及大环内酯类抗生素的祛痰作用。 Expectorants can be divided into reflex expectorants, irritating expectorants, mucus regulators, mucolytics and mucus promoting agents. Traditional mucus regulators are bromine new and carbocisteine, pulmonary sensory neuropeptide release inhibitors, tachykinin antagonists, inhibitors of media synthase and MUC gene inhibitors are currently more studied new Mucus regulators, this article discusses the molecular mucosal modulators of the new research progress and macrolide antibiotics expectorant effect.