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目的探讨脑梗死与颈动脉粥样硬化斑块及纤维蛋白原水平的关系。方法对84例脑梗死患者和40例对照组进行颈动脉彩色多普勒超声检查。并检测两组的血浆纤维蛋白原水平。结果病例组斑块检出率80.5%,显著高于对照组斑块检出率15.8%(P<0.001)。颈动脉分叉处硬化斑块检出率约为60%,显著高于颈总动脉和颈内动脉斑块检出率(25%,21%)(P<0.001)。病例组软斑块检出率(48/84)显著高于对照组检出率(13/40)(P<0.001)。病例组纤维蛋白原水平较对照组明显升高。结论脑梗死发病与颈动脉粥样硬化斑块相关。软斑块与脑梗死发病有一定关系。纤维蛋白原可能在动脉粥样斑块发生发展中起重要作用。
Objective To investigate the relationship between cerebral infarction and carotid atherosclerosis plaque and fibrinogen levels. Methods Eighty-four patients with cerebral infarction and 40 control subjects underwent color Doppler ultrasonography of carotid artery. Plasma fibrinogen levels were measured in both groups. Results The detection rate of plaque in case group was 80.5%, which was significantly higher than that in control group (15.8%, P <0.001). Carotid bifurcation of the hardened plaque detection rate was about 60%, significantly higher than the common carotid artery and carotid artery plaque detection rate (25%, 21%) (P <0.001). Soft plaque detection rate (48/84) in case group was significantly higher than that in control group (13/40) (P <0.001). The level of fibrinogen in the case group was significantly higher than that in the control group. Conclusion The incidence of cerebral infarction is related to carotid atherosclerotic plaque. Soft plaque and cerebral infarction have a certain relationship. Fibrinogen may play an important role in the development of atherosclerotic plaques.