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为探讨蓝光治疗对新生儿姊妹染色体单体交换（ＳＣＥ）及微核频率的影响，将蓝光治疗新生儿高胆红素血症患儿分为光疗＞７２小时的甲组（１６例），光疗≤７２小时的乙组（１８例）。另设对照组２０例，分别在光疗前、光疗后、恢复期检测了ＳＣＥ及微核水平。结果：（１）光疗前除甲组ＳＣＥ低于对照组外，余差异无显著意义（Ｐ均＞０．０５）；（２）甲组ＳＣＥ水平光疗后、恢复期均高于光疗前，且恢复期又高于光疗后（Ｐ均＜０．０１）；乙组光疗后、恢复期ＳＣＥ水平均有所下降；（３）光疗后、恢复期微核阳性率差异有显著意义（Ｐ＜０．０５，＜０．０１），且甲组高于乙组及对照组。提示光疗时间以７２小时内为宜，以避免光疗对染色体的损伤。
To investigate the effect of blue light therapy on neonatal sibling chromosome exchange (SCE) and micronuclei frequency, children with neonatal hyperbilirubinemia treated with blue light were divided into group A (16 cases) with phototherapy> 72 hours, light therapy Group B (18 cases) ≤72 hours. Another 20 cases of control group, respectively, before phototherapy, phototherapy, convalescent detection of SCE and micronuclei. Results: (1) There was no significant difference in residual SCE before phototherapy in control group (P> 0.05). (2) SCE in group A was significantly higher than that before phototherapy in SCE (P <0.01). The level of SCE in convalescent phase of group B decreased after phototherapy. (3) After phototherapy, there was significant difference in the positive rate of micronucleus in convalescent phase (P <0.01) .05, <0.01), and group A was higher than group B and control group. Prompt phototherapy time within 72 hours is appropriate, in order to avoid phototherapy of chromosomal damage.