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过多的胆固醇沉积在动脉壁对机体极为有害,可以引起动脉粥样硬化甚至心血管疾病.而胆固醇逆转运(reverse cholesterol transport,RCT)可以逆转此过程.传统的RCT是指胆固醇由外周组织转运回肝脏进行再循环或以胆汁酸的形式随粪便排出体外的过程,此过程受多种因子调控.近几年研究发现,胆固醇还可由血经过肠道直接分泌(transintestinal cholesterol efflux,TICE)通路随粪便排出体外,此过程对外界刺激更敏感.RCT已经成为防治动脉粥样硬化研究的新靶点,TICE有可能成为更有效的RCT调控通路.
Excessive cholesterol deposition in the arterial wall is extremely harmful to the body and can cause atherosclerosis and even cardiovascular disease.Reverse cholesterol transport (RCT) reverses this process.Traditional RCT refers to the transport of cholesterol from peripheral tissues The process of recycling back to the liver or excreting it in the form of bile acids with excretion is regulated by a variety of factors.Recent studies have found that cholesterol can also be transported by the transfusion of intestinal transit efflux (TICE) Excretion of feces from the body, the process more sensitive to external stimuli.RCT has become a new target for prevention and treatment of atherosclerosis research, TICE may become more effective RCT regulatory pathway.