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目的观察达纳康对高血压脑小动脉硬化的作用及预防脑卒中的效果。方法采用肾血管性高血压大鼠（ＲＨＲ）模型，选择与高血压动脉硬化相关的有害因子ＡⅠ、ＡⅡ、ＡＬＤ、ＥＴ及具有扩张血管作用的ＳＯＤ和ｃＧＭＰ，观察其在高血压形成的早期和晚期分别给于达纳康口服后的改变及与高血压脑小动脉硬化的关系。结果高血压组和晚期喂药组动脉硬化较严重，ＡⅠ、ＡⅡ、ＡＬＤ、ＥＴ均接近正常组水平，ＳＯＤ和ｃＧＭＰ增多。结论尽早防治高血压小动脉硬化可减少脑卒中的发生。
Objective To observe the effect of Danakang on hypertensive cerebral arteriosclerosis and stroke prevention. Methods Renal vascular hypertensive rats (RHR) model were selected to select the relevant factors of hypertension, such as AⅠ, AⅡ, ALD and ET, and SOD and cGMP with dilation of blood vessels. The changes of dacroner after oral administration and the relationship with hypertensive cerebral arteriosclerosis in the late stage respectively. Results The arteriosclerosis was more serious in the hypertensive group and the late feeding group. The levels of AⅠ, AⅡ, ALD and ET were close to those of the normal group, and the levels of SOD and cGMP increased. Conclusion Early prevention and treatment of hypertensive arteriosclerosis can reduce the incidence of stroke.