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目的:调查采取干预措施前后围手术期抗菌药合理用药情况,推动医院合理用药工作的开展。方法:选择2006年1～6月普外科、骨外科、泌尿外科、神经外科择期手术病历300份作为非干预组,分析围手术期预防应用抗菌药物存在的问题,制订相应的干预措施。在实施干预措施后另选取2007年1～6月上述科室择期手术病历300份作为干预组。分析两组病例抗菌药预防应用结果。结果:抗菌药的合理用药比例由干预前的22.00%上升到干预后的81.33%(P<0.05);基本合理比例由干预前的9.33%增加为干预后的10.33%(P<0.05);干预前围手术期预防性应用抗菌药存在的主要问题,在干预后均有显著改善。结论:实施围手术期预防应用抗菌药干预措施行之有效,值得借鉴。
Objective: To investigate the rational use of antibacterials during perioperative period before and after the interventions were taken to promote the rational use of drugs in hospitals. Methods: From January 2006 to June 2006, 300 cases of general surgery, orthopedics, urology and neurosurgery were selected as the non-intervention group to analyze the problems in perioperative prevention and treatment of antimicrobial agents and to make corresponding interventions. After the implementation of interventions, another 300 cases of the above-mentioned department’s elective surgical records from January to June 2007 were selected as the intervention group. Analysis of two groups of anti-bacterial drug application results. Results: The proportion of rational use of antibacterials increased from 22.00% before intervention to 81.33% after intervention (P <0.05), and the basic reasonable proportion increased from 9.33% before intervention to 10.33% after intervention (P <0.05) Preoperative perioperative prophylactic use of antimicrobial drugs exist in the main problems were significantly improved after intervention. Conclusion: The implementation of perioperative prevention and treatment of antimicrobial interventions effective and worth learning.