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用左旋多巴治疗帕金森病,使近期临床疗效有了显著的提高。但由于95％以上的左旋多巴是在胃肠道、肾、肝、血管内皮细胞等周围组织内脱羧,变成多巴胺,为周围组织利用,因而大量服用左旋多巴,常发生食欲不振、恶心、呕吐等消化道症状或心律不齐、体位性低血压等心血管系副作用。并用多巴脱羧酶抑制剂,既可阻止周围组织脱羧、减少周围副作用,也使血中多巴浓度增加,
Treatment of Parkinson’s disease with levodopa has led to a significant improvement in recent clinical outcomes. However, since more than 95% of levodopa is decarboxylated in the surrounding tissues such as the gastrointestinal tract, kidney, liver and vascular endothelial cells and becomes dopamine, which is utilized by the surrounding tissues, and thus levodopa taken in large amounts often causes loss of appetite and nausea , Vomiting and other gastrointestinal symptoms or arrhythmia, orthostatic hypotension and other cardiovascular system side effects. And with dopa decarboxylase inhibitors, both to prevent the surrounding tissue decarboxylation and reduce the surrounding side effects, but also to increase the blood concentration of dopa,