目的　通过分析 2型糖尿病大鼠胰岛 β细胞磺脲类药物受体 (SUR)mRNA转录水平探讨其发病机制。方法　采用逆转录 -聚合酶链反应 (RT -PCR)技术 ,在大鼠注射链脲菌素后 0、4、8、12、2 4周取其血和胰腺 β细胞分别测定血糖、胰岛素、血脂和SURmRNA转录水平。结果　在第 8周大鼠的血糖和胰岛素已开始升高 ,胰岛 β细胞SURmRNA转录水平降低 ,到 2 4周与对照组有极显著差异 (P <0 .0 1)。 结论　在链脲菌素所致 2型糖尿病大鼠模型中SURmRNA转录水平有显著改变 ,SUR表达水平下降可能是 2型糖尿病致病原因之一 Objective To investigate the pathogenesis of pancreatic β-cell sulfonylurea receptor (SUR) mRNA transcription in type 2 diabetic rats. Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the levels of blood glucose, insulin, and lipids in blood and pancreatic β-cells at 0,4,8,12,24 weeks after injection of streptozotocin And SURmRNA transcription level. Results At the 8th week, the level of blood glucose and insulin began to increase and the level of SURmRNA in islet β cells decreased. There was a significant difference between the control group and the 24th week (P <0.01). Conclusion The level of SUR mRNA expression in type 2 diabetic rats induced by streptozotocin significantly changes. The decrease of SUR expression may be one of the causes of type 2 diabetes